Antioxidant in red wine has no benefit at low doses

— The antioxidant resveratrol does not improve longevity when consumed at levels naturally occurring in foods like grapes, red wine and dark chocolate, according to a new study published Monday in the journal JAMA Internal Medicine.

“We looked at the relationship between resveratrol levels and a lot of health outcomes that are thought to be related to resveratrol, such as cancer and heart disease and lifespan. And we found no relationship,” says Dr. Richard Semba, study author and professor at Johns Hopkins University School of Medicine.

The potential health benefits of consuming moderate amounts of red wine have been much discussed ever since researchers identified the “French paradox” – an observation that the French have lower levels of heart disease despite consuming relatively high amounts of saturated fat.

Some epidemiologists proposed that France’s relatively high rates of red wine consumption may help explain the supposed paradox, and further studies have shown that light to moderate alcohol consumption does in fact correlate with healthier hearts. The new study does not contradict these conclusions.

More recently, researchers at Harvard Medical School and the National Institutes of Health identified a specific chemical in red wine – resveratrol – that seems to significantly delay the effects of aging in mice, when given in very high doses.

Today, Americans spend some $30 million per year on resveratrol supplements, even though there have been no long-term studies in humans to measure resveratrol’s effect on longevity.

So researchers from Johns Hopkins University and the University of Barcelona tracked 783 men and women aged 65 or older, analyzing who survived and who died over a nine-year period in relation to their resveratrol levels.

The results show no benefits – in terms of longevity, reduced inflammation, heart disease or cancer – to having higher levels of resveratrol versus lower or moderate levels.

However, study participants’ resveratrol came only from their diets – consuming foods like red wine, chocolate, and berries – which provides almost negligible amounts of resveratrol compared to the levels found in supplements and studied in mice.

In fact, a person would have to drink hundreds of glasses of red wine a day to match the amounts used in previous resveratrol studies.

“This study is very important because it demonstrates, in a long-term study with a huge cohort, that (normal) dietary resveratrol levels are not correlated with all-cause mortality,” says Juan Carlos Espin, a research professor at the Spanish National Research Council.

“However, to claim that resveratrol does not have influence on the all-cause of mortality would require the comparison of a cohort with ‘normal’ resveratrol levels (very low and unpredictable) versus another cohort with a standardized resveratrol supplementation.”

The-CNN-Wire

™ & © 2014 Cable News Network, Inc., a Time Warner Company. All rights reserved.

Consumer Reports: Too many sodas contain potential carcinogen

— A chemical found in many sodas may be dangerous to your health, Consumer Reports says. And no, it’s not sugar (this time).

The golden-brown color of many soft drinks comes with a dose of the chemical 4-methylimidazole, or 4-MeI. On U.S. product labels it appears simply as “caramel coloring.”

Those who say the chemical may possibly cause cancer include the World Health Organization’s International Agency for Research on Cancer and the state of California, which now limits manufacturers to 29 micrograms of exposure for the average consumer per day.

Foods exceeding that limit have to carry a warning label that reads: “WARNING: This product contains a chemical known to the State of California to cause cancer.”

But when Consumer Reports purchased sodas in California and had them analyzed by a lab, it found that one 12-ounce serving of Pepsi One or Malta Goya exceeded the levels permitted without a warning label.

Ten other brands tested by the group did meet the California standard, which is estimated to limit the risk of cancer from 4-MeI to one case in every 100,000 lifetimes of daily exposure.

“We are concerned about both the levels of 4-MeI we found in many of the soft drinks tested and the variations observed among brands, especially given the widespread consumption of these types of beverages,” said Dr. Urvashi Rangan, a Consumer Reports toxicologist, in a statement.

“There is no reason why consumers need to be exposed to this avoidable and unnecessary risk that can stem from coloring food and beverages brown.”

The Food and Drug Administration does not set federal limits on 4-MeI in food, and the data gathered by Consumer Reports show that in some cases consumers outside California are drinking a slightly different ingredient. For example, Pepsi One purchased by the group in December in New York contains four times as much 4-MeI as the same product bought that same month in California.

In a statement to Consumer Reports, PepsiCo Inc. said data indicate that the average person consumes less than one-third a can of diet soda per day; therefore, its product meets the California standard, even if a complete serving exceeds that limit.

In addition to new federal standards, Consumer Reports is calling on the FDA to “require labeling of specific caramel colors in the ingredient lists of food where it is added, so consumers can make informed choices.”

Currently the FDA has no reason to believe that 4-Mel poses a health risk to consumers at the levels found in foods with caramel coloring, agency spokeswoman Juli Putnam told CNN in an e-mail. The government agency is testing a variety of food and beverages with the chemical and reviewing safety data to determine if any regulatory action needs to be taken, she said.

Consumers interested in more information on 4-Mel can check out the FDA’s FAQ page.

“First and foremost, consumers can rest assured that our industry’s beverages are safe,” the American Beverage Association said in a statement. “Contrary to the conclusions of Consumer Reports, FDA has noted there is no reason at all for any health concerns, a position supported by regulatory agencies around the world.

“However, the companies that make caramel coloring for our members’ soft drinks are now producing it to contain less 4-MeI, and nationwide use of this new caramel coloring is underway.”

The-CNN-Wire

™ & © 2014 Cable News Network, Inc., a Time Warner Company. All rights reserved.